For some horses, an allhay diet may reduce the efficacy of omeprazole in treating ulcers, according to a new study from Australia.
Omeprazole, a so-called proton-pump inhibitor, reduces the amount of acid released in the stomach; low gastric pH is associated with the development of gastric ulcers. Developed for use in human medicine, omeprazole (trade name GastroGard) is the most commonly prescribed ulcer medication for horses.
To see whether diet influences how omeprazole is absorbed by the horse’s body, Ben Sykes, BVMS, PhD, of the University of Queensland, measured changes in stomach pH in six healthy horses receiving oral omeprazole under a variety of conditions. Two diets were studied: an all-hay ration in which horses had constant access to forage, and a high-grain, low-fiber ration, in which the horses effectively…
